C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/40 (2006.01) A61K 31/662 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07F 9/38 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01) C07F 9/6533 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01)
Patent
CA 2386848
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of formula (I), some are known and others are new. The novel compounds constitute another aspect of the invention.
La présente invention concerne des compositions utiles pour le traitement ou la surveillance d'états pathologiques associés à des protéinases renfermant du zinc, et tout particulièrement à des métalloprotéinases. L'ingrédient actif de ces compositions est un alpha-oxo- ou un alpha-thioxophosphonate représenté par la formule générale (I). En dehors des phosphonates de la formule générale (I), certains sont déjà connus et d'autres sont nouveaux. L'invention concerne également ces nouveaux composés.
Breuer Eli
Reich Reuven
Salomon Claudio
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Yissum Research Development Company Of The Hebrew University Of
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