A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 31/337 (2006.01) A61K 47/42 (2006.01) A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2620585
The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
La présente invention propose des compositions comprenant un agent pharmaceutique peu soluble dans l'eau, une protéine porteuse, et un agent antimicrobien, dans lesquelles une croissance microbienne significative est inhibée. La quantité de l'agent antimicrobien dans la composition peut être au-dessous du niveau qui induit un effet toxicologique ou à un niveau auquel un effet secondaire potentiel peut être contrôlé ou toléré. L~invention concerne également des compositions comprenant un agent pharmaceutique peu soluble dans l'eau, une protéine porteuse, un sucre, et facultativement un agent antimicrobien. L~invention concerne en outre des procédés d'utilisation des compositions.
Desai Neil P.
Selvaraj Raj
Soon-Shiong Patrick M.d.
Yang Andrew
Abraxis Bioscience Llc
Smart & Biggar
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