Compositions comprising semaphorins for the treatment of...

Details Compositions comprising semaphorins for the treatment of... Compositions comprising semaphorins for the treatment of...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 35/00 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2702655

A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Methods of treating angiogenesis, kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.

L'invention concerne un procédé de sélection d'une sémaphorine pour le traitement du cancer chez un sujet. Le procédé comprend la détermination d'une expression d'un récepteur de sémaphorine sur des cellules tumorales d'un échantillon tumoral d'un sujet, une quantité du récepteur de sémaphorine étant indicative de la sémaphorine appropriée pour le traitement du cancer chez le sujet. L'invention concerne également des procédés de traitement de l'angiogenèse, des kits pour le traitement du cancer et des compositions pharmaceutiques qui comprennent des sémaphorines.

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