Compositions comprising t cell receptors and methods of use...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) A61K 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2580412

Nucleic acids encoding antitumor TCRs recognizing MART-1, NY-ESO-1, and melanoma gp100 peptides; vectors and cells comprising the same; and methods of using the foregoing.

La présente invention décrit des acides nucléiques codant pour des TCR antitumoraux dirigés contre MART-1, NY-ESO-1, et les peptides de mélanome gp100. La présente invention a également pour objet des vecteurs et des cellules incluant ces acides nucléiques, ainsi que des méthodes d'utilisation desdits acides nucléiques, vecteurs et cellules.

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