Compositions comprising temozolomide and thalidomide and...

A - Human Necessities – 61 – K

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Details

A61K 31/4188 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/724 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2436886

This invention relates to compositions comprising temozolomide and thalidomide which can be used in the treatment of prevention of cancer, in particular malignant melanoma, cancer of the skin, subcutaneous tissue, lymph nodes, brain, lung, liver, bone, intestine, colon, heart, pancreas, adrenals, kidney, prostate, breast, colorectal, or a combination thereof. A particular composition comprises temozolomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, and thalidomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof. The invention also relates to methods of treating or preventing cancer, in particular malignant melanoma, cancer of the skin, subcutaneous tissue, lymph nodes, brain, lung, liver, bone intestine, colon, heart, pancreas, adrenals, kidney, prostate, breast, colorected, or a combination thereof, which comprise the administration of temozolomide and thalidomide and another anti-cancer drug to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of cancer chemotherapy or radiation therapy which comprise the administration of temozolomide and thalidomide to a patient in need of such reduction or avoidance.

L'invention concerne des compositions renfermant de la temozolomide et de la thalidomide, qui peuvent être utilisées dans le traitement ou la prévention du cancer, notamment le mélanome malin, le cancer de la peau, du tissu sous-cutané, des ganglions lymphatiques, du cerveau, du poumon, du foie, des os, de l'intestin, du côlon, du coeur, du pancréas, des glandes surrénales, du rein, de la prostate, du sein, colorectal ou toute combinaison de ceux-ci. Une composition particulière comprend de la temozolomide ou un sel, un solvate ou un clathrate pharmaceutiquement acceptable de celle-ci ; et de la thalidomide ou un sel, un solvate ou un clathrate pharmaceutiquement acceptable de celle-ci. L'invention concerne aussi des méthodes de traitement ou de prévention du cancer, notamment le mélanome malin, le cancer de la peau, du tissu sous-cutané, des ganglions lymphatiques, du cerveau, du poumon, du foie, des os, de l'intestin, du côlon, du coeur, du pancréas, des glandes surrénales, du rein, de la prostate, du sein, colorectal ou toute combinaison de ceux-ci, qui comprennent l'administration à un patient nécessitant un tel traitement ou une telle prévention, de temozolomide et de thalidomide ainsi que d'un autre anticancéreux. L'invention concerne de plus des procédés visant à réduire ou à éviter des effets indésirables associés à l'administration de chimiothérapie ou de radiothérapie anticancéreuses, qui comprennent l'administration de temozolomide et de thalidomide à un patient nécessitant un tel traitement ou une telle prévention.

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