A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2302522
Certain novel compositions of the adjuvant saponin QS-21 having improved properties are disclosed. The compositions of the present invention are designed (1) to minimize the lytic effects of QS-21, (2) to improve the tolerance of QS-21 containing formulations in humans or other animals, (3) to stabilize the QS-21 from alkaline hydrolysis and/or (4) to maintain the high adjuvant potency of the QS-21 product. These compositions may be employed with vaccines comprising proteins or peptides, polysaccharides, lipids, or nucleic acids.
L'invention concerne de nouvelles compositions d'adjuvant de saponine QS-21 qui possèdent des propriétés améliorées. Les compositions de la présente invention sont conçues (1) pour réduire au minimum les effets lytiques de QS-21, (2) améliorer la tolérance, chez l'être humain ou l'animal, de formulations renfermant QS-21, (3) stabiliser QS-21 contre une hydrolyse alcaline et/ou (4) maintenir la forte activité adjuvante du produit de QS-21. Ces compositions peuvent être employées avec des vaccins comportant des protéines ou des peptides, des polysaccharides, des lipides ou des acides nucléiques.
Beltz Gerald A.
Kensil Charlotte
Antigenics Inc.
Aquila Biopharmaceuticals Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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