Compositions comprising weakly basic drugs and...

Details Compositions comprising weakly basic drugs and... Compositions comprising weakly basic drugs and...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2721083

The present invention is directed to pharmaceutical compositions, and methods of making such compositions, comprising microparticles containing a weakly basic drug core, a layer of alkaline buffer, and a controlled-release coating. The present invention is also directed to pharmaceutical dosage forms, including orally disintegrating tablets, conventional tablets, and capsules, and methods for their preparation.

La présente invention concerne des compositions pharmaceutiques, et des procédés de préparation de ces compositions, comprenant des microparticules contenant un noyau médicamenteux faiblement basique, une couche de tampon alcalin, et un enrobage à libération contrôlée. La présente invention concerne également des formes posologiques pharmaceutiques, parmi lesquelles des comprimés à délitement oral, des comprimés classiques, et des capsules, et des procédés pour les préparer.

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