Compositions containing...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/444 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2412199

Medicines for the prevention and treatment of neurodegenerative diseases which are useful in the prevention and/or treatment of neurodegenerative diseases such as Alzheimer's disease and schizophrenia of mammals (including human beings) through the retardation or inhibition of neurodegeneration due to hypofunction of glutamic acid receptor and which contain as the active ingredient 5-substituted -3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives of the general formula (I) or physiologically acceptable acid-addition salts thereof wherein Het is oxadiazolyl; R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, lower alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or the like; and R2 is hydrogen, lower alkyl, lower cycloalkyl, substituted or unsubstituted aryl, or the like.

L'invention porte sur des médicaments utilisés dans la prévention et le traitement de maladies neurodégénératives et qui sont utiles dans la prévention et/ou le traitement de maladies neurodégénératives telles que la maladie d'Alzheimer et la schizophrénie chez les mammifères (y compris l'homme), le procédé consistant à retarder ou en inhiber la neurodégénération due à l'hypofonction du récepteur de l'acide glutamique. Ces médicaments contiennent, comme ingrédients actifs, des dérivés de 5-substitué-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one de la formule générale (I) dans laquelle Net représente oxadiazolyle ; R<1> représente hydrogène, alkyle inférieur, cycloalkyle inférieur, alcényle inférieur, alcoxy inférieur, aryle substitué ou non substitué, hétéroaryle substitué ou non substitué ou analogue ; et R<2> représente hydrogène, alkyle inférieur, cycloalkyle inférieur, aryle substitué ou non substitué ou analogue.

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