A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/12 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/197 (2006.01) A61K 31/205 (2006.01) A61K 31/355 (2006.01) A61K 31/415 (2006.01) A61K 31/455 (2006.01) A61K 31/525 (2006.01) A61K 31/661 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2327095
The present invention relates to the use of creatine compound and neuroprotective combinations including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds in combination with neuroprotective agents can be used as therapeutically effective compositions against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Hungtington's disease, amyotropic lateral sclerosis, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase; and (4) N-phosphorocreatine analogs bearing non- transferable moieties which mimic the N-phosphoryl group.
L'invention concerne l'utilisation de composés de créatine combinés à des agents neuroprotecteurs, comprenant de la créatine, de la phosphocréatine ou les analogues de créatine tels que la cyclocréatine, pour le traitement des maladies du système nerveux. Les composés de créatine combinés à des agents neuroprotecteurs peuvent être utilisés comme compositions thérapeutiquement efficaces contre diverses maladies du système nerveux telles que les neuropathies diabétiques et toxiques, les maladies du système nerveux périphérique, la maladie d'Alzheimer, la maladie de Parkinson, les ictus, la chorée de Huntington, la sclérose latérale amyotrophique, les maladies des motoneurones, les lésions traumatiques des nerfs, la sclérose en plaque, la démyélinisation et les pathologies associées à cette dernière, ainsi que les maladies mitochondriales. Les composés de créatine qui conviennent comprennent (1) la créatine, la phosphocréatine et les analogues de ces composants pouvant agir comme substrats ou analogues de substrat pour la créatine kinase; (2) des inhibiteurs à deux substrats de créatine kinase comprenant des analogues structurels à liaison covalente d'adénosine triphosphate (ATP) et de créatine; (3) des analogues de créatine qui peuvent agir comme inhibiteurs réversibles ou irréversibles de la créatine-kinase; et (4) des analogues de N-phosphocréatine comprenant des fractions non transférables imitant le groupe N-phosphoryle.
Beal M. Flint
Kaddurah-Daouk Rima
Avicena Group Inc.
Borden Ladner Gervais Llp
The General Hospital Corporation
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