Compositions containing a ruthenium(iii) complex and a...

A - Human Necessities – 61 – K

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A61K 31/416 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01) A61K 33/24 (2006.01)

Patent

CA 2436260

The invention relates to compositions containing a ruthenium (III) complex and a heterocycle, a method for the production thereof, a pharmaceutical containing said compositions and a kit. The invention also relates to a composition (A) which can be obtained by reacting a compound of general formula (I) M3-n-p-2pr[RuX6-n-p-2rBn(H2O)p(OH)q(O)r]2r+1 (I) with a compound of general formula (II) B'(HX')s (II). The invention further relates to a composition (B) which can be obtained by mixing a compound of general formula (III) (B'H)3-n-p-2pr[RuX6-n-p-2rBn(H2O)p(OH)q(O)r]2r+1 (III) with a compound of general formula (IV) MX' (IV). Fig.1. A. living cells B. concentration (µM) Indazol = indazole

L'invention concerne une composition (A) que l'on peut obtenir en faisant réagir un composé correspondant à la formule générale (I): M¿3?-n-p-2pr[RuX¿6-n-p-q-2r?B¿n?(H¿2?O)¿p?(OH)¿q?(O)¿r?]¿2r+1? avec un composé correspondant à la formule générale (II): B'(HX')¿s?. L'invention concerne en outre une composition (B) que l'on peut obtenir en mélangeant un composé correspondant à la formule générale (III): (B'H)¿3-n-p-2pr?[RuX¿6-n-p-q-2r?B¿n?(H¿2?O)¿p?(OH)¿q?(O)¿r?]¿2r+1? avec un composé correspondant à la formule générale (IV): MX'.

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