A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/60 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2199642
The invention relates to the use of a synthetic oligosaccharide which is a selective inhibitor of factor Xa acting via antithrombin III, alone or in association with aspirin, for the preparation of medicaments intended for preventing or treating thromboembolic diseases occurring in a mammal which has undergone a percutaneous transluminal angioplasty. The subject of the invention is moreover pharmaceutical compositions for the treatment or prophylaxy of thromboembolic diseases occurring in a mammal which has undergone a percutaneous transluminal angioplasty, comprising the association of an effective quantity of at least one synthetic oligosaccharide, which is a selective inhibitor of factor Xa acting via antithrombin III, and of an effective quantity of aspirin, optionally mixed with one or more pharmaceutically acceptable excipients.
L'invention porte sur l'utilisation d'un oligosaccharide qui est un inhibiteur sélectif du facteur Xa agissant sur l'antithrombine III, seul ou en association avec l'aspirine, en vue de la préparation de médicaments destinés à prévenir ou à traiter les affections thromboemboliques survenant chez un mammifère ayant subi une angioplastie transluminale percutanée. L'invention porte de plus sur des compositions pharmaceutiques destinées à traiter ou à prévenir les désordres thromboemboliques survenant chez un mammifère qui a subi une angioplastie transluminale percutanée, comportant l'association d'une quantité efficace d'au moins un oligosaccharide synthétique, qui est un inhibiteur sélectif du facteur Xa agissant sur l'antithrombine III, et d'une quantité efficace d'aspirine, pouvant facultativement être mélangée à un ou plusieurs excipients acceptables sur le plan pharmaceutique.
Cariou Roger
Stiekema Jacobus Christianus Johannes
Akzo Nobel Nv
Robic
Sanofi
Sanofi-Aventis
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