Compositions containing bergamottin for increasing the oral...

Details Compositions containing bergamottin for increasing the oral... Compositions containing bergamottin for increasing the oral...

A - Human Necessities

61

K

A61K 31/37 (2006.01) A61K 31/35 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2291233

Bergamottin, a principle compound in grapefruit juice responsible for inhibition of P450 3A4, the predominant P450 enzyme in the intestine, is coadministered with a compound having low bioavailability to a patient to increase oral bioavailability of the compound and pharmaceutical compositions of the same, as well as a method of isolating BG from grapefruit juice.

La bergamottine, qui est un composé principe actif du jus de pamplemousse responsable de l'inhibition de la P450 3A4, l'enzyme P450 prédominante de l'intestin, est administrée dans le corps d'un patient conjointement avec un composé ayant une biodisponibilité basse, afin d'accroître la biodisponibilité orale dudit composé. Cette invention se rapporte en outre à des compositions pharmaceutiques de ce composé, ainsi qu'à un procédé permettant d'isoler la bergamottine du jus de pamplemousse.

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