Compositions containing growth factors and antiplastic agents

Details Compositions containing growth factors and antiplastic agents Compositions containing growth factors and antiplastic agents

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2149657

The intraocular use of combinations of lens epithelial cell growth stimulators (e.g., TGF-.beta.) and antimetabolites (e.g., mitomycin C) is described. The combination is applied to the capsular bag to prevent or retard the formation of secondary cataracts following cataract surgery. The lens epithelial cell stimulators activate DNA synthesis in dormant lens epithelial cells, and thereby make those cells susceptible to the antimetabolites. This enables the antimetabolites to suppress the proliferation of lens epithelial cells to a much greater extent, relative to the proliferation observed when the metabolites alone are utilized. The increased suppression of the growth of lens epithelial cells results in a significant improvement in the ability to prevent or retard the formation of opacities on the lens capsule (i.e., secondary cataracts).

L'invention porte sur l'emploi intra-oculaire de mélanges de stimulateurs de croissance de cellules épithéliales du cristallin (p. ex. TGF-.beta.) et d'antimétabolites (p. ex. la mitomycine C) qui s'appliquent sur la poche capsulaire pour prévenir ou retarder la formation de cataractes secondaires à des opérations de la cataracte. Les stimulateurs des cellules épithéliales du cristallin activent la synthèse d'ADN dans les cellules épithéliales dormantes du cristallin, ce qui a pour effet de les rendre sensibles aux antimétabolites lesquels sont alors en mesure de supprimer la prolifération des cellules épithéliales du cristallin dans une proportion nettement plus élevés que lorsqu'on utilise les métabolites seuls. Cette limitation accrue de la croissance des cellules épithéliales du cristallin se traduit par une amélioration significative de la capacité de prévenir ou retarder la formation d'opacités sur la capsule du cristallin (p. ex. cataractes secondaires).

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