Compositions containing ibuprofen

Details Compositions containing ibuprofen Compositions containing ibuprofen

A - Human Necessities

61

K

167/262

A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/19 (2006.01)

Patent

CA 1309351

COMPOSITIONS CONTAINING IBUPROFEN Abstract of the Disclosure: A granular composition containing 2-(4- isobutylphenyl)propionic acid (ibuprofen) as an active anti-inflammatory pharmaceutical ingredient as a major component, together with carboxymethylcel- lulose, a lubricant and water as minor components, is disclosed. Particles of ibuprofen and carboxy- methylcellulose are both fluidized and coated with an aqueous dispersion of a starch binder. After being dried to a moisture level of about 1-5% and blended with a lubricant and additional carboxymethylcel- lulose, the resulting granules can be directly molded into a pharmaceutically acceptable tablet having high hardness, short disintegration time and fast dis- solution rate.

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