C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/26 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07D 209/40 (2006.01) C07D 213/74 (2006.01) C07D 215/38 (2006.01) C07D 239/42 (2006.01) C07D 277/40 (2006.01) C07D 307/66 (2006.01) C07D 307/82 (2006.01) C07D 333/26 (2006.01) C07D 333/68 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 2/00 (2006.01) C07K 14/61 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2631491
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post- translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non- natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
L'invention concerne des acides aminés non naturels et des polypeptides qui comprennent au moins un acide aminé non naturel et des procédés servant à fabriquer de tels acides aminés et polypeptides non naturels. Les acides aminés non naturels, seuls ou en tant que partie d'un polypeptide, peuvent inclure une large palette de fonctionnalités possibles, mais ont typiquement au moins un groupe amine aromatique. L'invention concerne également des polypeptides d'acides aminés non naturels qui sont en plus modifiés de façon post-traductionnelle, des procédés servant à effectuer de telles modifications et des procédés servant à purifier de tels polypeptides. Typiquement, les polypeptides d'acides aminés non naturels modifiés incluent au moins un groupe amine alkylé. L'invention concerne en outre des procédés d'utilisation de tels polypeptides d'acides aminés non naturels et polypeptides d'acides aminés non naturels modifiés, dont des utilisations thérapeutiques, de diagnostic et d'autres utilisations en biotechnologie.
Liu Junjie
Miao Zhenwei
Norman Thea
Ambrx Inc.
Smart & Biggar
LandOfFree
Compositions containing, methods involving, and uses of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions containing, methods involving, and uses of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions containing, methods involving, and uses of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1404889