A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01)
Patent
CA 2632832
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non- natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-tran slationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
L'invention concerne des acides aminés non naturels et des polypeptides qui comprennent au moins un acide aminé non naturel et des procédés servant à fabriquer de tels acides aminés et polypeptides non naturels. Les acides aminés non naturels, par eux-mêmes ou en tant que partie d'un polypeptide, peuvent comprendre une large palette de fonctionnalités possibles, mais ils ont généralement au moins un groupe hétérocyclique, à base d'aldol, dicarbonyle et/ou diamine. L'invention concerne également des polypeptides d'acides aminés non naturels qui sont en plus modifiés de façon post-traductionnelle, des procédés servant à effectuer de telles modifications et des procédés servant à purifier de tels polypeptides. Généralement, les polypeptides d'acides aminés non naturels comprennent au moins un groupe hétérocyclique, à base d'aldol, dicarbonyle et/ou diamine. L'invention concerne en outre des procédés d'utilisation de tels polypeptides d'acides aminés non naturels et de polypeptides d'acides aminés non naturels modifiés, dont des utilisations thérapeutiques, de diagnostic et d'autres utilisations en biotechnologie.
Liu Junjie
Miao Zhenwei
Ambrx Inc.
Smart & Biggar
LandOfFree
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