C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/14 (2006.01) C07D 209/80 (2006.01)
Patent
CA 2672205
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, but typically have at least one indole, carbonyl, and/or hydrazine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one indole, carbonyl, and/or hydrazine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
L'invention concerne des acides aminés non naturels et des polypeptides renfermant au moins un acide aminé non naturel ainsi que des procédés permettant de produire de tels acides aminés non naturels et polypeptides. Les acides aminés non naturels, eux-seuls ou comme partie d'un polypeptide, peuvent présenter une large gamme de fonctionnalités, mais possèdent normalement au moins un groupe indole, carbonyle et/ou hydrazine. L'invention concerne également des polypeptides d'acides aminés non naturels modifiés post-traductionnellement, des procédés pour apporter ces modifications et des procédés de purification desdits polypeptides. Normalement, les polypeptides d'acides aminés non naturels modifiés renferment au moins un groupe indole, carbonyle et/ou hydrazine. L'invention concerne en outre des procédés d'utilisation desdits polypeptides d'acides aminés non naturels et polypeptides d'acides aminés non naturels modifiés, y compris des utilisations thérapeutiques, diagnostiques et autres utilisations en biotechnologie.
Liu Junjie
Miao Zhenwei
Ambrx Inc.
Smart & Biggar
LandOfFree
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