Compositions containing opioid antagonists

Details Compositions containing opioid antagonists Compositions containing opioid antagonists

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61P 1/08 (2006.01) A61P 1/10 (2006.01)

Patent

CA 2628786

Compositions containing opioid antagonists are disclosed, particularly alvimopan and its active metabolite in solid dosage forms, where the drug is uniformly distributed, achieves the desired bioavailability, and is stable. Methods of preparing and using the compositions containing opioid antagonists are also disclosed. The results are achieved by a combination of processing techniques and component selection.

La présente invention se rapporte à des compositions contenant des antagonistes opioïdes, en particulier de l'alvimopan et son métabolite actif, dans des formes posologiques solides dans lesquelles le médicament est uniformément réparti, présente la biodisponibilité désirée, et est stable. L'invention a également trait à des procédés de préparation et d'utilisation desdites compositions contenant des antagonistes opioïdes. Les résultats obtenus sont le fruit d'une combinaison de techniques de traitement et de la sélection des composants.

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