Compositions containing prodrugs of florfenicol and methods...

A - Human Necessities – 61 – K

Patent

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A61K 31/14 (2006.01) A61K 31/045 (2006.01)

Patent

CA 2531223

The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. in another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.

L'invention concerne des compositions et des procédés d'administration de florfenicol à des mammifères. Ces compositions contiennent un promédicament de florfenicol dans un excipient pharmaceutiquement acceptable. Dans une forme de réalisation, le promédicament est une forme estérisée de florfenicol. Les promédicaments adéquats comprennent par exemple un ou plusieurs des éléments suivants en combinaison : acétate de florfenicol, propionate de florfenicol, butyrate de florfenicol, pentanoate de florfenicol, hexanoate de florfenicol, heptanoate de florfenicol, octanoate de florfenicol, nanoate de florfenicol, décanoate de florfenicol, undécanoate de florfenicol, dodécanoate de florfenicol et phtalate de florfenicol. Dans une autre forme de réalisation, le promédicament est transformé en florfenicol in vivo sous l'action d'une ou de plusieurs estérases endogènes. L'invention concerne aussi de nouveaux composés, des compositions pharmaceutiques contenant ces composés et des procédés d'administration de celles-ci.

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