A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7076 (2006.01) A61K 33/32 (2006.01) A61P 39/00 (2006.01)
Patent
CA 2695950
This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
L'invention concerne des procédés visant à conserver une fonction protéique par la mise en contact d'une protéine avec une composition comprenant un ou plusieurs nucléosides de purine (tels que l'adénosine ou l'uridine, par exemple) et un antioxydant (tel que le manganèse, par exemple). L'invention concerne de plus des procédés visant à traiter et/ou à prévenir un effet secondaire de l'exposition à un rayonnement et des procédés visant à prévenir un effet secondaire d'une radiothérapie, qui comprennent l'administration, à un sujet nécessitant un tel traitement, d'une quantité pharmaceutiquement efficace d'une composition comprenant un ou plusieurs nucléosides de purine (tels que l'adénosine ou l'uridine, par exemple) et un antioxydant (tel que le manganèse, par exemple). Lesdites compositions peuvent comprendre des extraits de D. radiodurans.
Daly Michael J.
Gaidamakova Elena K.
Levine Rodney L.
Matrosova Vera K.
Wehr Nancy B.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
The Henry M. Jackson Foundation For The Advancement Of Military Inc.
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