Compositions containing tumor rejection antigen precursors...

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) A61K 9/127 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2201327

Compositions with improved immunogenic effect are disclosed. The compositions contain one or more peptides which, when complexed with a cell surface molecule, such as an MHC, HLA or B cell receptor, provoke an immune response. The compositions contain adjuvants such as saponins, which potentiate the immune response. Especially preferred are compositions which stimulate cytolytic T cell responses, such as peptides which satisfy criteria for MHC binding, such as peptides derived from tumor rejection antigen precursors, including MAGE, BAGE, and GAGE derived peptides.

L'invention se rapporte à des compositions présentant de meilleurs effets immunogènes. Ces compositions contiennent au moins un peptide qui, lorsqu'il est complexé à une molécule d'une surface cellulaire, telle qu'un MCH (complexe majeur d'histocompatibilité), HLA (système majeur d'histocompatibilité) ou un récepteur des lymphocytes B, provoque une réponse immune. Les compositions renferment des adjuvants tels que les saponines qui potentialisent la réponse immune. Les compositions notamment préférées sont celles qui stimulent les réponses cytolytiques des lymphocytes T, tels que les peptides qui satisfont aux critères de liaison du CMH, et tels que les peptides dérivés des précurseurs d'antigènes de rejet de tumeurs, y compris les peptides dérivés de MAGE, BAGE et GAGE.

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