A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/56 (2006.01)
Patent
CA 2403671
Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus ("MM") and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
L'invention concerne des compositions comprenant un tissu mou isolé de Modiolus modiolus ("MM") et des compositions comprenant une huile isolée de MM ou d'une partie de MM. Elle concerne également des méthodes de traitement de l'adénocarcinome chez un sujet; des méthodes pour diminuer la prolifération de cellules d'adénocarcinome, ou induire l'apoptose des cellules d'adénocarcinome, ou induire la différenciation des cellules d'adénocarcinome dans des cellules non cancéreuses. L'invention concerne des méthodes inhibant l'activité de 5-lipoxygénase et/ou de 12-lipoxygénase; et des méthodes pour traiter un sujet atteint d'une maladie ou d'une pathologie associée à une activité excessive de 5-lipoxygénase et/ou de 12-lipoxygénase. L'invention concerne en outre un procédé de préparation d'un extrait de MM, qui consiste à placer MM ou une partie de MM au contact d'un solvant dans des conditions permettant d'en extraire un ou plusieurs matériaux.
Adrian Thomas E.
Collin Peter D.
Creighton University
Gowling Lafleur Henderson Llp
LandOfFree
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