Compositions derived from mycobacterium vaccae and methods...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/04 (2006.01) A61K 48/00 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2315539

The present invention provides compositions which are present in or may be derived from Mycobacterium vaccae, together with methods for their use in the treatment, prevention and detection of disorders including infectious diseases, immune disorders and cancer. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate, delipidated M. vaccae cells, delipidated and deglycolipidated M. vaccae cells depleted of mycolic acids, and delipidated and deglycolipidated M.vaccae cells depleted of mycolic acids and arabinogalactan are also provided.

La présente invention concerne des compositions présentes dans Mycobacterium vaccae ou pouvant être dérivées de cette dernière, ainsi que leurs méthodes d'utilisation dans le traitement, la prévention et la détection d'affections, y compris de maladies infectieuses, d'affections immunitaires et du cancer. L'invention concerne également des méthodes d'activation de la réponse immunitaire à un antigène, y compris l'administration d'un filtrat de culture de M. vaccae, de cellules de M. vaccae délipidées, de cellules de M. vaccae dépourvues d'acides mycoliques délipidées et déglycolipidées et de cellules de M. vaccae dépourvues d'acides mycoliques et d'arabinogalactane, délipidées et déglycolipidées.

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