Compositions enriched in neoplastic stem cells and methods...

Details Compositions enriched in neoplastic stem cells and methods... Compositions enriched in neoplastic stem cells and methods...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) G01N 33/574 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2658003

A neoplastic stem cell population enriched for expression of the OCT4 transcription factor as well as methods for their identification, isolation and enrichment are described. The OCT4-enriched neoplastic stem cell population is further utilized for the induction and analysis of cancer in an animal. In addition, methods of preventing, abrogating, or inhibiting cancer, tumor growth, and metastasis via OCT4 inhibition are further provided.

La présente invention concerne une population de cellules souches néoplasiques enrichie permettant l'expression du facteur de transcription OCT4, ainsi que des procédés destinés à son identification, son isolement et son enrichissement. La population de cellules souches néoplasiques enrichie en OCT4 est en outre utilisée pour induire et analyser un cancer chez un animal. L'invention concerne également des procédés de prévention, de suppression ou d'inhibition du cancer, du développement tumoral, et des métastases grâce à l'inhibition du OCT4.

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