Compositions for a once a day treatment of cyclooxygenase-2...

A - Human Necessities – 61 – K

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A61K 31/365 (2006.01)

Patent

CA 2254121

This invention is directed to a pharmaceutical composition for the treatment of cyclooxygenase-2 mediated diseases, said composition being suitable for once a day oral administration, said composition comprising 2.5 to 250 mgs of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl)-2-(5H)-furanone. The invention is also directed to a method of treating cyclooxygenase-2 mediated diseases comprising the once a day oral administration of 2.5 to 250 mgs of 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl)-2-(5H)- furanone. The invention is also directed to the use of 5,5-dimethyl-3-(3- fluorophenyl)-4-(4-methylsulfonyl)phenyl)-2-(5H)-furanone in the manufacture of a medicament containing 2.5 to 250 mgs of said compound for once a day administration for the treatment of cyclooxygenase-2 mediated diseases.

L'invention concerne une composition pharmaceutique de traitement de maladies à médiation cyclooxygénase-2, cette composition pouvant être administrée une fois par jour par voie orale et contenant de 2,5 à 250 mg de 5,5 -diméthyl-3-(3 fluorophényl)-4-(4-méthylsulfonyl)phényl)-2-(5H)-furanone. L'invention concerne également une méthode pour traiter les maladies à médiation cyclooxygénase-2 comprenant l'administration d'une dose quotidienne de 2,5 à 250 mg de 5,5 -diméthyl-3-(3 fluorophényl)-4-(4-méthylsulfonyl)phényl)-2-(5H)-furanone. L'invention concerne également une utilisation de 5,5 -diméthyl-3-(3 fluorophényl)-4-(4-méthylsulfonyl)phényl)-2-(5H)-furanone dans la production d'un médicament contenant entre 2,5 et 250 mg dudit composé à administrer à raison d'une dose quotidienne pour le traitement de maladies à médiation cyclooxygénase-2.

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