Compositions for administering rnaiii-inhibiting peptides

Details Compositions for administering rnaiii-inhibiting peptides Compositions for administering rnaiii-inhibiting peptides

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2605551

Compositions comprising RIP are advantageously formulated in compositions allowing sustained release and protection from degradation, and improved therapeutic efficacy. To that end, RIP compositions may be delivered to the skin or mucosal membranes as a salve or the like. Alternatively or additionally, RIP compositions may be administered in polymeric nanoparticle carriers, which may be biodegradable. Such formulations are compatible with oral administration. The nanoparticle may accommodate a composition comprising a RIP and at least one other antimicrobial agent, e.g., an antibiotic or an antimicrobial peptide. The nanoparticle further may comprise a coating or moiety, such as an antibody or fragment thereof, to assist in cell targeting.

L~invention concerne des compositions comprenant des peptides inhibant l~ARNIII (RIP) qui sont avantageusement formulées dans des compositions permettant une libération soutenue et une protection contre la dégradation, et présentent une efficacité thérapeutique améliorée. À cette fin, les compositions de RIP peuvent être administrées sur les membranes cutanées ou des muqueuses sous la forme d~un onguent ou analogue. En outre, ou en variante, des compositions de RIP peuvent être administrées dans des excipients de nanoparticules polymères, pouvant être biodégradables. De telles formules peuvent être administrées oralement. La nanoparticule peut accompagner une composition comprenant un RIP et au moins un agent antimicrobien, par exemple un peptide antibiotique ou antimicrobien. La nanoparticule peut en outre comprendre un revêtement ou un groupement, tel qu~un anticorps ou un fragment de celui-ci, pour aider au ciblage de cellules.

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