Compositions for affecting weight loss

Details Compositions for affecting weight loss Compositions for affecting weight loss

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/138 (2006.01) A61K 31/485 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2522708

Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance .alpha.-MSH activity.

La présente invention concerne des compositions influant sur la perte de poids qui comprennent un premier composé et un second composé, le premier composé étant un antagoniste opioïde et le second composé entraînant un agonisme accru du récepteur de mélanocortine 3 (MC3-R) ou du récepteur de mélanocortine 4 (MC4-R) comparé à un état physiologique normal. Cette invention concerne aussi des techniques influant sur la perte de poids, augmentant la dépense d'énergie, augmentant la sensation de satiété d'une personne ou supprimant l'appétit d'une personne, qui consistent à identifier une personne qui peut tirer profit de ces techniques et à traiter cette personne de façon à antagoniser l'activité du récepteur d'opioïde et à renforcer l'activité a-MSH.

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