Compositions for and methods of granzyme b inhibition

Details Compositions for and methods of granzyme b inhibition Compositions for and methods of granzyme b inhibition

A - Human Necessities

61

K

A61K 38/57 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2623957

The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.

L'invention repose sur la découverte que la serpina3n, une protéine sécrétée, se lie au granzyme B et en inhibe l'activité. L'invention porte par conséquent sur des cellules qui comprenent un polynucléotide codant une serpine inhibitrice du granzyme B, sur des compositions pharmaceutiques comprenant une serpine inhibitrice du granzyme B ou sur un polynucléotide codant une serpine inhibitrice du granzyme B, sur des procédés permettant de traiter un patient qui a besoin d'une immunosuppression en lui administrant une serpine inhibitrice du granzyme B, et sur des procédés permettant de transplanter des cellules (p.ex., des îlots de Langerhans) exprimant une serpine inhibitrice du granzyme B.

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