C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2147873
The present invention provides methods and composition for stimulating the immune system and thereby causing reduction, lysis and/or necrosis of tumors and slowing the progression of diseases including cancer, autoimmune diseases and diseases caused by viral infection. In particular is provided a cytokine containing and methods of obtaining the same from comprising culturing the cells on fresh medium, harvesting the culture supernatant in the absence of filtration of the supernatant, and maintaining the supernatant until administration the supernatant thereby being a composition for administration. Additionally provided are methods of treating cancers, autoimmune diseases and viral infections comprising administering the supernatant compositions.
Ces compositions et procédés permettent de stimuler le système immunitaire et donc de favoriser la réduction, la lyse et/ou la nécrose des tumeurs et de ralentir l'évolution de maladies au rang desquelles il convient de classer les cancers, les maladies auto-immunes et les maladies provoquées par une infection virale. En l'occurrence, la composition contient de la cytokine, et les procédés concernent l'obtention de cette composition à base de cytokine par cultures de cellules sur un milieu frais, puis à prélever ce qui surnage de la culture sans procédér à la moindre filtration, à conserver les produits surnageant jusqu'au moment de l'administration, ces produits surnageant constituant la composition à administrer. L'invention concerne aussi des procédés de traitement des cancers, des maladies auto-immunes et des infections virales par administration de ces compositions surnageantes.
Rodgers Thomas M. Jr.
Theodore T. Ronald
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Private Biologicals Corporation
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