Compositions for binding to assay substrata and methods of...

G - Physics – 01 – N

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G01N 33/574 (2006.01) G01N 33/537 (2006.01)

Patent

CA 2590188

Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for example, lyotropic liquid and/or liquid crystalline materials) and may contain macromolecular standards, markers or capture compounds. The compositions are capable of binding to assay substrata such as that of chips that are employed for MALDI and SELDI mass spectroscopy analyses and plates that are used for ELISA type assays.

Cette invention concerne des compositions et des procédés permettant d'établir une liaison avec des substrats d'essai de manière stable et protectrice, ce qui améliore les performances d'essai. Les compositions comprennent des matériaux lyotropiques (tels que des matériaux liquides et/ou cristallins liquides lyotropiques) et peuvent renfermer des modèles macromoléculaires, des marqueurs ou des composés de capture. Les compositions sont capables de se lier à des substrats d'essai tels que ceux de puces qui sont utilisées dans des dosages par spectroscopie de masse MALDI et SELDI et de plaques qui sont utilisées dans des dosages de type ELISA.

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