Compositions for boron neutron capture therapy and methods...

Details Compositions for boron neutron capture therapy and methods... Compositions for boron neutron capture therapy and methods...

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 9/127 (2006.01) A61K 41/00 (2006.01) C01B 35/18 (2006.01)

Patent

CA 2162995

Boron neutron capture therapy can utilize XyB20H17L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH3, and Na2B10H9NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered 10B and/or to increase the tumor specificity of the liposome.

Une thérapie par capture neutronique au bore peut utiliser XyB20H17L où X représente un métal alcalin, y vaut de 1 à 4, et L représente un donneur de deux électrons tel que NH3, et Na2B10H9NCO, entre autres. Ces sels de borane peuvent être utilisés à l'état libre ou encapsulés dans des liposomes. Les liposomes peuvent être inclus dans leurs carboranes bicouches afin d'augmenter la quantité de <10>B administrée et/ou d'accentuer la spécificité tumorale du liposome.

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