Compositions for cell adhesion inhibition and methods of use

Details Compositions for cell adhesion inhibition and methods of use Compositions for cell adhesion inhibition and methods of use

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2067183

2067183 9104745 PCTABS00003 Compositions that disrupt microvascular endothelial and epithelial cell tight junctions, and methods of use, are disclosed. Such compositions comprise agents that inhibit the binding to such cells of cell adhesion molecules. Such inhibitor agents include cell adhesion molecules, fragments of cell adhesion molecules that encompass a cell-binding domain such as HAV, and antibodies directed against cell adhesion molecules and fragments thereof. Also disclosed are drug delivery compositions comprising a therapeutic drug conjugated to an agent that disrupts cell tight junctions.

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