A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/06 (2006.01) A61K 31/19 (2006.01) A61K 31/70 (2006.01) A61K 33/04 (2006.01) A61P 9/14 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2149408
Injectable preparations of the composition for curing affected abnormal tissues are prepared by formulating sodium hydrogen sulfite with all the other components except tannic acid to yield a first mixture and adding tannic acid to the first mixture or by formulating a water-soluble aluminum compound and a chelating agent to yield a first formulation, formulating tannic acid and sodium hydrogen sulfite to yield a second formulation and admixing the first formulation with the second formulation to yield a second mixture and, as needed, adding a poly-valent alcohol and/or a saccharide to the first and/or second formulations or to the first or second mixture. This preparation can prevent tannic from being oxidized and from reacting directly with an aluminum ion derived from sodium hydrogen sulfite, whereby the composition having a stable formulation can be provided. The resulting compositions for curing the affected abnormal tissues is stable in quality and constant in formulation.
On produit une composition pour injection, destinée à traiter des tissus présentant des lésions, soit en combinant du sulfite acide de sodium et différents ingrédients autres que l'acide tannique selon un ordre arbitraire, puis en y ajoutant de l'acide tannique, soit en préparant une composition comprenant un composé d'aluminium soluble dans l'eau et un composé chélaté, puis une autre composition comprenant de l'acide tannique et du sulfite acide de sodium, en mélangeant ces deux compositions et en ajoutant, le cas échéant, un alcool polyvalent et/ou un saccharide à l'une de ces compositions ou aux deux ou au mélange des deux. Le procédé décrit ci-dessus permet de prévenir l'oxydation de l'acide tannique et des ions aluminium provenant du sulfate d'aluminium-potassium, ce qui permet d'obtenir une composition stable pour injections, d'une composition chimique constante.
Blake Cassels & Graydon Llp
Lequio Pharma Co. Ltd.
Mitsubishi Tanabe Pharma Corporation
Traditional Chinese Medicine Research Laboratory Inc.
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