Compositions for delivering peptide yy and pyy agonists

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01)

Patent

CA 2573512

The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and at least one of peptide YY (PYY) and a PYY agonist. Preferably, the composition includes a therapeutically effective amount of peptide YY or the PYY agonist and the delivery agent compound. The composition of the present invention facilitates the delivery of PYY, a PYY agonist, or a mixture thereof and increases its bioavailability compared to administration without the delivery agent compound. PPY and PYY agonists possess activity as agents to reduce nutrient availability, including reduction of food intake.

L'invention concerne une composition (p. ex. composition pharmaceutique) qui comprend au moins un composé d'agent d'apport et le peptide YY (PYY) et/ou un agoniste du PYY. De préférence, la composition comprend une quantité thérapeutiquement efficace du peptide YY ou de l'agoniste du PYY, et le composé d'agent d'apport. Cette composition facilite l'apport du PYY, d'un agoniste du PYY ou d'un mélange de ceux-ci et accroît leur biodisponibilité par rapport à une administration n'utilisant pas le composé d'agent d'apport. Le PPY et les agonistes du PYY présentent une activité visant à réduire la disponibilité des nutriments, y compris l'apport alimentaire.

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