Compositions for delivery of a cortisol antagonist

Details Compositions for delivery of a cortisol antagonist Compositions for delivery of a cortisol antagonist

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 31/00 (2006.01) A61K 31/03 (2006.01) A61K 31/167 (2006.01) A61K 31/245 (2006.01) A61K 31/375 (2006.01) A61K 31/4164 (2006.01) A61K 31/4166 (2006.01) A61K 31/4168 (2006.01) A61K 31/4174 (2006.01) A61K 31/444 (2006.01) A61K 31/451 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/567 (2006.01) A61K 31/569 (2006.01) A61K 31/58 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2397065

The present invention relates to compositions for controlled release of a cortisol antagonist comprising at least one release rate controlling substance together with said cortisol antagonist and methods of preventing or treating metabolic syndrome, diabetes mellitis type II or symptoms or complications thereof in a mammal, which method comprises administering such a composition to said mammal in an amount effective to treat one or more of the clinical manifestations of metabolic syndrome or diabetes mellitis type II as well as complications thereof.

La présente invention concerne des compositions permettant la libération contrôlée d'un antagoniste de cortisol, comprenant au moins une substance de régulation de la vitesse de libération ainsi que ledit antagoniste de cortisol. Cette invention concerne également des procédés de prévention et de traitement du syndrome métabolique, du diabète mellitis de type II ou des symptômes ou complications qui en résultent, chez un mammifère. Ledit procédé comprend l'administration d'une composition de ce type audit mammifère en une quantité efficace pour traiter une ou plusieurs des manifestations cliniques du syndrome métabolique, ou diabètemellitis de type II ainsi que des complications qui en résultent.

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