C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 47/48 (2006.01) C07K 7/66 (2006.01) C07K 14/435 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2352645
A novel transfection reagent is disclosed comprising a conjugate of a lipid and a basic membrane disturbing peptide of the formula (see formula I) wherein R1 and R2 are selected from the group consisting of hydrocarbyl moieties of straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acids and phospholipid moieties, R3 is a basic, membrane-disturbing peptide with a reversed amide backbone, Y is a C2-10 alkylene, and X is selected from the group consisting of -C(O)-NH-, -S-S-, and salts thereof. Particularly preferred compounds are those wherein R1 and R2 independently are an acyl moiety of a C12-20 carboxylic acid, especially wherein R1 and R2 are oleoyl. Further disclosed is a transfection method in which transfection efficiency and DNA complex formation are enhanced by the use of a compound of the invention in conjunction with an amino acid concentrate in the form of a protein hydrolysate.
Kitas Eric Argirios
Schlaeger Ernst-Juergen
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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