A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 31/17 (2006.01) A61K 31/351 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2526122
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, a composition is disclosed the includes a G1 phase arresting agent and an antiviral agent, wherein the combination synergically enhances the activity of the antiviral agent.
La présente invention concerne l'insensibilisation de la cellule au facteur de l'expression CCR5 du récepteur de surface par la manipulation du cycle cellulaire dans des lymphocytes activés au moyen de l'administration d'une composition qui met fin à la phase G1 du cycle cellulaire, ce qui permet de diminuer les sites récepteurs d'entrée du VIH dans des lymphocytes T et, donc, les effets du VIH. En outre, cette invention a trait à une composition qui renferme un agent d'arrêt de la phase G1 et un agent antiviral, la combinaison synergique permettant d'améliorer l'activité de l'agent antiviral.
Amoroso Anthony
Davis Charles E. Jr.
Heredia Alonso
Redfield Robert R.
Kirby Eades Gale Baker
University Of Maryland - Biotechnology Institute
LandOfFree
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