Compositions for expression of proteins in host cells using...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) C07K 14/78 (2006.01) C07K 14/815 (2006.01) C12N 15/12 (2006.01) C12N 15/15 (2006.01) C12N 15/79 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2219821

Hybrid genes comprising a nucleotide sequence encoding a preprocollagen signal sequence operatively linked to a nucleotide sequence encoding a heterologous protein are disclosed. The hybrid genes are useful for secretion of heterologous proteins from host cells. In a preferred embodiment, the signal sequence of the human preprocollagen .alpha.1(I) protein is linked to a heterologous protein of interest to allow for secretion of the protein from Hansenula polymorpha cells.

La présente invention concerne des gènes hybrides comprenant une séquence nucléotidique codant une séquence-signal de préprocollagène fonctionnellement liée à une séquence nucléotidique codant une protéine hétérologue. Ces gènes hybrides conviennent à la sécrétion de protéines hétérologues à partir de cellules hôtes. Dans une réalisation préférée, la séquence-signal de la protéine du préprocollagène .alpha.1(I) d'origine humaine se lie à la protéine hétérologue considérée pour permettre la sécrétion de la protéine issue de cellules de Hansenula polymorpha.

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