A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2708145
The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and wherein the second adjuvant comprises an imidazoquinoline compound, and (c) a pharmaceutically acceptable excipient, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
L'invention porte, entre autres, sur des compositions immunogènes qui comprennent (a) un premier antigène, (b) au moins des premier et second adjuvants, le premier adjuvant comprenant des microparticules, et le second adjuvant comprenant un composé imidazoquinoléine, et (c) un excipient pharmaceutiquement acceptable, lesquelles compositions déclenchent une réponse immunitaire lorsqu'elles sont administrées à un sujet vertébré. L'invention porte également sur des procédés de fabrication de compositions immunogènes et sur des procédés d'utilisation des compositions immunogènes (par exemple, pour un traitement), entre autres avantages.
Malyala Padma
O'hagan Derek T.
Singh Manmohan
Borden Ladner Gervais Llp
Novartis Ag
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