A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 45/00 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2524217
The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
L'invention concerne, entre autres, des compositions immunogènes comprenant un premier antigène, au moins deux adjuvants, le premier adjuvant contenant un polymère dérivé de poly(lactides) et/ou de poly(lactide-co-glycolides), et le second adjuvant comprenant un imidazoquinoline, ledit premier antigène étant encapsulé dans, adsorbé ou conjugué à, co-lyophilisé ou mélangé audit premier adjuvant, ainsi qu'un excipient pharmaceutiquement acceptable. Cette composition élicitant une réponse immunitaire cellulaire lorsqu'elle est administrée à un vertébré. Par ailleurs, l'invention concerne des procédés de production de compositions immunogènes, des procédés de production d'une réponse immunitaire induite par les cellules T tueuses (CTL) chez un vertébré, et enfin, des procédés d'immunisation.
O'hagan Derek
Singh Manmohan
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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