Compositions for inhalation

Details Compositions for inhalation Compositions for inhalation

A - Human Necessities

61

K

A61K 47/28 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 38/00 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 47/12 (2006.01) A61K 47/24 (2006.01) A61K 47/26 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2166109

Pharmaceutical compositions containing a mixture of a pharmaceutically active polypeptide and an enhancer compound which enhances the systemic absorption of the polypeptide in the lung of a patient, the mixture being in the form of a dry powder, in which at least 50 % of the total mass of polypeptide and enhancer consists of primary particles having a diameter less than or equal to about 10 microns, the primary particles optionally being formed into agglomerates; and methods of delivering such compositions by inhalation.

Préparation pharmaceutique faite d'un mélange d'un polypeptide à activité pharmaceutique et d'un renforçateur de l'absorption systémique du polypeptide par l'appareil pulmonaire du patient. Le mélange se présente sous la forme d'une poudre sèche dans laquelle au moins 50 % de la masse des deux composants consiste en particules primaires, d'un diamètre inférieur ou égal à environ 10 microns, pouvant facultativement être agglomérées. L'invention porte également sur une méthode d'administration de cette préparation par inhalation.

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