Compositions for inhibiting grb7

Details Compositions for inhibiting grb7 Compositions for inhibiting grb7

A - Human Necessities

61

K

A61K 38/06 (2006.01) A61K 31/711 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) C07K 1/04 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2427858

The invention provides methods and compositions for treating subjects using Grb7 antagonists. Specifically disclosed are Grb7 antagonists that bind selectively to Grb7 and interfere with the ability of Grb7 to bind to its native ligands. These compositions are useful in the prevention and treatment of disorders characterized by abnormal interaction of Grb7 with its native ligands (e.g., ErbB2).

L'invention concerne des méthodes et des compositions destinées à traiter des sujets au moyen d'antagonistes de Grb7. Plus particulièrement, l'invention concerne des antagonistes de Grb7 se liant sélectivement à Grb7 et interférant avec la capacité de Grb7 à se lier à ses ligands endogènes. Ces compositions sont utiles dans la prévention et le traitement de troubles caractérisés par une interaction anormale de Grb7 avec ses ligands endogènes (ErbB2, par exemple).

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