C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2594234
The present invention relates a method for screening for a PARP activator. The screening method comprises the step of assessing the PARP-activating effect of a test compound, using cells, cell lysate, or purified PARP. The present invention also provides a method for the treatment of cancers. The treatment method comprises administering to the subject a therapeutically effective amount of a PARP activator.
L'invention concerne un procédé pour cribler un activateur de PARP, ce procédé consistant à évaluer l'effet activant de PARP d'un composé test, au moyen de cellules, de lysat cellulaire ou de PARP purifiée. La présente invention porte également sur une méthode de traitement de cancers, cette méthode consistant à administrer au malade une quantité thérapeutiquement suffisante d'un activateur de PARP.
Li Chiang
Sun Xiangao
Wang Aijin
Arqule Inc.
Ridout & Maybee Llp
LandOfFree
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