Compositions for neuronal tissue regeneration

Details Compositions for neuronal tissue regeneration Compositions for neuronal tissue regeneration

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61K 9/00 (2006.01) A61K 9/52 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61L 31/00 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2515192

A biocompatible, biodegradable composition for encouraging controlled growth, regeneration or repair of biological tissue or cells, the composition comprising a scaffold, formed from biodegradable and biocompatible material, and a receptor for a growth factor, or a growth factor-binding fragment or homologue thereof, located at or adjacent a surface of the scaffold. The tissue or cells are preferably neuronal, in which case the receptor is preferably a tyrosine receptor kinase (Trk), or a neurotrophin-binding fragment or homologue thereof. Such a composition may include one or more types of neurotrophin bound to the Trk or fragment or homologue thereof.

L'invention concerne une composition biocompatible, biodégradable favorisant la croissance, la régénération ou la réparation contrôlés d'un tissu ou de cellules biologiques. Cette composition contient un échafaudage, formé à partir d'une matière biodégradable et biocompatible, ainsi qu'un récepteur pour un facteur de croissance ou un fragment de liaison au facteur de croissance ou homologue associé, situé sur ou adjacent à une surface de l'échafaudage. Le tissu ou les cellules sont de préférence neuronaux, auquel cas le récepteur est de préférence un récepteur tyrosine kinase (Trk), ou un fragment de liaison à la neurotrophine ou homologue associé. Ladite composition peut comporter un ou plusieurs types de neurotrophine liée au récepteur Trk ou fragment ou homologue associé.

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