Compositions for oral administration of sustained release...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 38/06 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2615319

A composition suitable for oral administration for sustained-release of glutathione, the composition comprising from about 50 % by weight to about 90 % by weight glutathione; from about 0 % by weight to about 10 % by weight binder; from about 10 % by weight to about 50 % by weight of at least one sustained release agent; and a granule size of from about 850 µm to about 5000 µm, is provided. Methods for preparing such compositions are also provided. Uses and methods of medical treatment comprising orally administering a composition for sustained release of glutathione to a patient suffering from or at risk of suffering from a neurological disorder are also provided.

L'invention concerne une composition appropriée pour administration par voie orale de glutathione à libération soutenue. Ladite composition comprend entre environ 50 % en poids et environ 90 % en poids de glutathione, entre environ 0 % en poids et environ 10 % en poids de liant; entre environ 10 % en poids et environ 50 % en poids d'au moins un agent de libération soutenue; la taille des granules est comprise entre environ 850 µm et environ 5000 µm. L'invention concerne également des procédés de préparation de ces compositions. Elle concerne enfin leurs utilisations et les procédés de traitement médical consistant à administrer par voie orale à un patient souffrant ou risquant de souffrir d'un trouble neurologique une composition de glutathione à libération soutenue.

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