Compositions for oral gene therapy and methods of using same

Details Compositions for oral gene therapy and methods of using same Compositions for oral gene therapy and methods of using same

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2462593

The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using manoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy.

L'invention concerne des compositions de nanoparticules comprenant un biopolymère cationique et au moins une substance active au niveau biologique, des compositions pharmaceutiques comprenant de telles nanoparticules ainsi que des procédés d'administration orale de molécules actives au niveau biologique et susceptibles de dégradation dans les voies gastro-intestinales mettant en oeuvre des nanoparticules. L'invention concerne également des compositions et des procédés permettant l'administration orale d'une thérapie génique.

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