Compositions for promoting nerve regeneration

Details Compositions for promoting nerve regeneration Compositions for promoting nerve regeneration

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2361289

Slit-N polypeptides are used to promote axon branching and nerve regeneration in vitro and in vivo. Pharmaceutical compositions comprising a therapeutically effective amount of a Slit-N polypeptide, a pharmaceutically acceptable excipient and/or neuroactive agents, particularly neurotrophins such as NGF ate used to treat neutopathies.

Des polypeptides Slit-N sont utilisés en vue de favoriser la ramification des axones et la régénération des tissus nerveux, in vitro et in vivo. L'invention concerne des compositions pharmaceutiques utilisées dans le traitement des neuropathies, contenant une dose d'un polypeptide Slit-N efficace d'un point de vue thérapeutique, un excipient pharmaceutiquement acceptable et/ou des agents neuroactifs, notamment des neurotrophines telles que le NGF.

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