Compositions for reducing, ameliorating, treating, or...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/734 (2006.01) A61K 47/36 (2006.01) A61P 27/04 (2006.01)

Patent

CA 2685230

Compositions for relief, treatment, or prevention of a condition of dry eye comprise alginate, a polyol, and a combinations of at least two organic acids or salts thereof, wherein the compositions have pH in the range from about 5 to about 7.5, at least one of the organic acids or salts thereof has a pKa in the range from and 6 to about 10. m some embodiments, the second organic acid or a salt thereof has a pKa that is no more than 1.5 units less than the pH.

L'invention concerne des compositions pour le soulagement, le traitement, ou la prévention d'une affection de kératoconjonctivite sèche, comprenant de l'alginate, un polyol, et des combinaisons d'au moins deux acides organiques ou de leurs sels, les compositions ayant un pH dans la plage d'environ 5 à environ 7,5, au moins un des acides organiques ou leurs sels ayant un pKa dans la plage de 6 à environ 10. Dans certains modes de réalisation, le deuxième acide organique ou un sel de celui-ci a un pKa qui n'est pas supérieur à 1,5 unité de moins que le pH.

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