Compositions for reducing bacterial carriage and cns...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/09 (2006.01) A61P 11/02 (2006.01) C07K 16/12 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2545325

Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a pneumococcal neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid, or an antigenic portion of either neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid. Optionally, the composition can comprise any combination of a pneumococcal neuraminidase, a phosphocholine, a pneumococcal teichoic acid, a pneumococcal lipoteichoic acid or an antigenic portion of any one of these. Optionally the agents are detoxified. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.

L'invention concerne des compositions conçues pour réduire ou prévenir les infections bactériennes (p. ex. les infections pneumococciques), le portage nasal, la colonisation nasale et l'invasion du système nerveux central. L'invention concerne une composition qui contient une neuraminidase pneumococcique, de la phosphocholine, de l'acide téichoïque pneumococcique, de l'acide lipotéichoïque pneumococcique, ou une fraction antigénique de neuraminidase, de phosphocholine, d'acide téichoïque pneumococcique, ou d'acide lipotéichoïque pneumococcique. Cette composition peut également comprendre une combinaison quelconque de neuraminidase pneumococcique, de phosphocholine, d'acide téichoïque pneumocoddique, d'acide lipotéichoïque pneumococcique ou d'une fraction antigénique de l'un ou l'autre de ces composants. Ces agents peuvent éventuellement être détoxiqués. L'invention concerne en outre des procédés de préparation et de méthodes d'utilisation de ces compositions. L'invention concerne plus spécifiquement des méthodes entraînant la production d'anticorps dans un sujet, consistant à administrer à ce dernier un agent ou une composition du type décrit. L'invention concerne enfin des méthodes permettant de réduire ou de prévenir le portage nasal ou l'infection pneumococcique chez un sujet, consistant à administrer à ce dernier une des compositions décrites.

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