Compositions for reducing oxidative injury

Details Compositions for reducing oxidative injury Compositions for reducing oxidative injury

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) A61K 38/44 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2096333

2096333 9208482 PCTABS00013 Compositions for reducing oxidative injury to an animal that includes a modified superoxide dismutase, wherein the modification comprises substituting a first amino acid residue located within 3-12 Å of the active site of the superoxide dismutase with a second amino acid residue capable of reacting with a highly reactive nitrating species, such as nitronium ion, formed from the reaction of peroxynitrite and superoxide dismutase.

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